Anatomical Model of Rat Ventricles to Study Cardiac Arrhythmias under Infarction Injury

Species-specific computer models of the heart are a novel powerful tool in studies life-threatening cardiac arrhythmias. Here, we develop such model aimed at studying infarction injury rat heart, most common experimental system to investigate effects myocardial damage. We updated Gattoni2016 cellular ionic by fitting its parameters data using population modeling approach. Using four selected models, studied 2D spiral wave dynamics and found that they include meandering break-up. Then, an anatomically realistic ventricular geometry fiber orientation built with post-infarction scar study electrophysiological A was simulated as inexcitable obstacle surrounded border zone modified cardiomyocyte properties. For rotation scroll waves that, depending on model, can observe different types dynamics: anchoring, self-termination or stable wave. The observed arrhythmia characteristics coincide those measured experiment. developed be used hearts damage from ischemia reperfusion examine possible arrhythmogenic various interventions.